Effect of Metformin on Animals Exposed to Acute Paracetamol Induced Toxicity
Student: Favour Ogechukwu Ashiedu (Project, 2025)
Department of Pharmacology
Delta State University, Abraka, Delta State
Abstract
ABSTRACT Background: Metformin is widely used for treating type 2 diabetes and has potential hepatoprotective effects. Paracetamol overdose, however, can lead to acute liver injury. Aim: To evaluate the effect of metformin on liver enzymes levels in animals exposed to acute paracetamol toxicity. Methods: Wistar rats were divided into four groups: normal control, paracetamol control, metformin-treated, and silymarin-treated. After inducing liver toxicity with paracetamol, liver enzyme levels (ALT, ALP, AST) were measured. Then blood samples were taken for biochemical analysis. Results: Paracetamol significantly increased liver enzyme levels, indicating liver injury. Metformin treatment significantly decreased ALT, ALP, and AST levels compared to the paracetamol control group, showing a protective effect. Conclusion: Metformin significantly mitigates liver enzyme elevation caused by paracetamol toxicity, suggesting its potential as a hepatoprotective agent.
Keywords
For the full publication, please contact the author directly at: ashiedu.favour@delsu.edu.ng
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Institutions
- Binyaminu Usman Polytechnic, Hadijia, Jigawa State 3
- Borno State University, Maiduguri, Borno State 15
- Bowen University, Iwo, Osun State 1
- Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 254
- College of Agriculture and Animal Science, Mando Road, Kaduna, Kaduna State 1
- College of Agriculture, Science and Technology, Lafia, Nasarawa State 8
- College of Education, Akwanga (affl To Ahmadu Bello Univ, Zaria) 1
- College of Education, Eha Amufu, (Affliliated To Unn), Enugu State 1
- College of Education, Warri (Affiliated To Delta State Uni, Abraka), Delta State 1
- College of Health Technology, Calabar, Cross River State 1