Effect of Metformin on Animals Exposed to Acute Paracetamol Induced Toxicity
Student: Favour Ogechukwu Ashiedu (Project, 2025)
Department of Pharmacology
Delta State University, Abraka, Delta State
Abstract
ABSTRACT Background: Metformin is widely used for treating type 2 diabetes and has potential hepatoprotective effects. Paracetamol overdose, however, can lead to acute liver injury. Aim: To evaluate the effect of metformin on liver enzymes levels in animals exposed to acute paracetamol toxicity. Methods: Wistar rats were divided into four groups: normal control, paracetamol control, metformin-treated, and silymarin-treated. After inducing liver toxicity with paracetamol, liver enzyme levels (ALT, ALP, AST) were measured. Then blood samples were taken for biochemical analysis. Results: Paracetamol significantly increased liver enzyme levels, indicating liver injury. Metformin treatment significantly decreased ALT, ALP, and AST levels compared to the paracetamol control group, showing a protective effect. Conclusion: Metformin significantly mitigates liver enzyme elevation caused by paracetamol toxicity, suggesting its potential as a hepatoprotective agent.
Keywords
For the full publication, please contact the author directly at: ashiedu.favour@delsu.edu.ng
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Institutions
- HASSAN USMAN KATSINA POLYTECHNIC (NCE), KATSINA, KATSINA STATE 4
- Hassan Usman Katsina Polytechnic, Katsina, Katsina State 5
- Heritage Polytechnic, Ikot Udota, Akwa Ibom State 46
- Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State 8
- Ibrahim Badamasi Babangida University, Lapai, Niger State 24
- Igbinedion University, Okada, Benin City, Edo State 2
- Ignatius Ajuru University of Education, Port Harcourt, Rivers State 8
- Imo State Polytechnic, Umuagwo, Owerri, Imo State 3
- Imo State University, Owerri, Imo State 45
- Institute of Management and Technology, Enugu, Enugu State 11