Effect of Metformin on Animals Exposed to Acute Paracetamol Induced Toxicity
Student: Favour Ogechukwu Ashiedu (Project, 2025)
Department of Pharmacology
Delta State University, Abraka, Delta State
Abstract
ABSTRACT Background: Metformin is widely used for treating type 2 diabetes and has potential hepatoprotective effects. Paracetamol overdose, however, can lead to acute liver injury. Aim: To evaluate the effect of metformin on liver enzymes levels in animals exposed to acute paracetamol toxicity. Methods: Wistar rats were divided into four groups: normal control, paracetamol control, metformin-treated, and silymarin-treated. After inducing liver toxicity with paracetamol, liver enzyme levels (ALT, ALP, AST) were measured. Then blood samples were taken for biochemical analysis. Results: Paracetamol significantly increased liver enzyme levels, indicating liver injury. Metformin treatment significantly decreased ALT, ALP, and AST levels compared to the paracetamol control group, showing a protective effect. Conclusion: Metformin significantly mitigates liver enzyme elevation caused by paracetamol toxicity, suggesting its potential as a hepatoprotective agent.
Keywords
For the full publication, please contact the author directly at: ashiedu.favour@delsu.edu.ng
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- Isa Mustapha Agwai I Polytechnic, Lafia, Nasarawa State 2
- Jigawa State Polytechnic, Dutse, Jigawa State 4
- Joseph Sarwuan Tarka University, Makurdi, Benue State 17
- Kaduna Polytechnic (NCE), Kaduna, Kaduna State 2
- Kaduna Polytechnic, Kaduna 329
- Kaduna Polytechnic, Kaduna , Kaduna State (affl To Fed Univ of Tech, Minna) 6
- Kaduna State College of Education, Gidan-Waya (affliatted To Abu) 2
- Kaduna State University, Kaduna, Kaduna State 247
- Kano State Polytechnic, Kano, Kano State 196
- Kano University of Science and Technology, Wudil, Kano State 6