Effect of Metformin on Animals Exposed to Acute Paracetamol Induced Toxicity
Student: Favour Ogechukwu Ashiedu (Project, 2025)
Department of Pharmacology
Delta State University, Abraka, Delta State
Abstract
ABSTRACT Background: Metformin is widely used for treating type 2 diabetes and has potential hepatoprotective effects. Paracetamol overdose, however, can lead to acute liver injury. Aim: To evaluate the effect of metformin on liver enzymes levels in animals exposed to acute paracetamol toxicity. Methods: Wistar rats were divided into four groups: normal control, paracetamol control, metformin-treated, and silymarin-treated. After inducing liver toxicity with paracetamol, liver enzyme levels (ALT, ALP, AST) were measured. Then blood samples were taken for biochemical analysis. Results: Paracetamol significantly increased liver enzyme levels, indicating liver injury. Metformin treatment significantly decreased ALT, ALP, and AST levels compared to the paracetamol control group, showing a protective effect. Conclusion: Metformin significantly mitigates liver enzyme elevation caused by paracetamol toxicity, suggesting its potential as a hepatoprotective agent.
Keywords
For the full publication, please contact the author directly at: ashiedu.favour@delsu.edu.ng
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Institutions
- Sokoto State University, Sokoto, Sokoto State 42
- St. Albert The Great Major Seminary, Abeokuta. (affl. To University of Benin) 1
- Sule Lamido University, Kafin Hausa, Jigawa State 4
- Tai Solarin University of Education, Ijagun, Ogun State 18
- Tansian University, Oba, Anambra State 1
- Taraba State University, Jalingo, Taraba State 32
- Temple-Gate Polytechnic, Osisioma, Abia State 1
- The Oke-Ogun Polytechnic, Saki, Oyo State 6
- The Polytechnic, Ibadan, Oyo State 13
- THOMAS ADEWUMI UNIVERSITY, OKO-IRESE, KWARA STATE 1