Effects of Immune Booster on Gastric Oxidative Marker in Lead Exposed Male Wistar Rats.
Student: Deborah Tomilolaninuoluwa Aigboviose (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Lead exposure is a significant environmental risk factor that can induce oxidative stress and impair gastric health. This study investigated the effects of an immune booster on gastric oxidative markers in lead-exposed male Wistar rats. Thirty male Wistar rats were divided into five groups: control, lead-exposed, lead-exposed + immune booster (low dose), lead-exposed + immune booster (high dose), and immune booster alone. Lead exposure was achieved through administration of lead acetate (100 mg/kg) for 4 weeks, while the immune booster was administered concurrently. Gastric tissues were assessed for malondialdehyde (MDA), glutathione (GSH), and catalase (CAT) activities.
Results showed that lead exposure significantly increased MDA levels (p
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- Kebbi State University of Science and Technology, Aliero, Kebbi State 6
- Kenule Benson Saro-Wiwa Polytechnic, Bori, Rivers State 18
- Kogi State Polytechnic, Lokoja, Kogi State 4
- Kogi State University, Anyigba 2
- Kwara State College of Health Technology, offa, Kwara State 9
- Kwara State Polytechnic, Ilorin, Kwara State 20
- Kwara State University, Malete, Ilorin, Kwara State 13
- Ladoke Akintola University of Technology, Ogbomoso, Oyo State 39
- Lagos State Poly, Ikorodu, Lagos State 2
- Lagos State University, Ojo, Lagos State 8