Effects of Immune Booster on Gastric Oxidative Marker in Lead Exposed Male Wistar Rats.
Student: Deborah Tomilolaninuoluwa Aigboviose (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Lead exposure is a significant environmental risk factor that can induce oxidative stress and impair gastric health. This study investigated the effects of an immune booster on gastric oxidative markers in lead-exposed male Wistar rats. Thirty male Wistar rats were divided into five groups: control, lead-exposed, lead-exposed + immune booster (low dose), lead-exposed + immune booster (high dose), and immune booster alone. Lead exposure was achieved through administration of lead acetate (100 mg/kg) for 4 weeks, while the immune booster was administered concurrently. Gastric tissues were assessed for malondialdehyde (MDA), glutathione (GSH), and catalase (CAT) activities.
Results showed that lead exposure significantly increased MDA levels (p
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- Covenant Polytechnic, Aba, Abia State 1
- Covenant University, Canaan Land, Ota, Ogun State 4
- Crawford University of Apostolic Faith Mission Faith City, Igbesa, Ogun State 2
- Crescent University, Abeokuta, Ogun State 1
- Cross Rivers University of Technology, Calabar, Cross Rivers State 142
- Delta State Polytechnic, Ogwashi-Uku, Delta State 11
- Delta State Polytechnic, Otefe, Delta State 12
- Delta State University, Abraka, Delta State 138
- Ebonyi State University, Abakaliki, Ebonyi State 17
- Edo University, Iyamho, Edo State 10