Effects of Immune Booster on Gastric Oxidative Marker in Lead Exposed Male Wistar Rats.
Student: Deborah Tomilolaninuoluwa Aigboviose (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Lead exposure is a significant environmental risk factor that can induce oxidative stress and impair gastric health. This study investigated the effects of an immune booster on gastric oxidative markers in lead-exposed male Wistar rats. Thirty male Wistar rats were divided into five groups: control, lead-exposed, lead-exposed + immune booster (low dose), lead-exposed + immune booster (high dose), and immune booster alone. Lead exposure was achieved through administration of lead acetate (100 mg/kg) for 4 weeks, while the immune booster was administered concurrently. Gastric tissues were assessed for malondialdehyde (MDA), glutathione (GSH), and catalase (CAT) activities.
Results showed that lead exposure significantly increased MDA levels (p
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- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 116
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14