Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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Institutions
- Novena University, Ogume, Delta State 1
- Nuhu Bamalli Polytechnic, Zaria, Kaduna State 7
- Nwafor Orizu College of Education, Nsugbe, Anambra State 1
- Obafemi Awolowo University, Ile-Ife, Osun State 15
- Oduduwa University, Ipetumodu, Osun State 9
- Ogun State College of Health Technology, Ilese-Ijebu, Ogun State 1
- Ogun State Institute of Tech(formerly Gateway Ict Poly), Igbesa, Ogun State 4
- Olabisi Onabanjo University, Ago-Iwoye, Ogun State 38
- Ondo State University of Medical Sciences, Laje Road, Ondo, Ondo State 1
- Osun State College of Education, Ila-Orangun 1