Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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Institutions
- Redeemers University, Ede, Osun State 4
- Rhema University, Aba, Abia State 11
- Rivers State University of Science and Technology, Port Harcourt, Rivers State 3
- RIVERS STATE UNIVERSITY, PORT HARCOURT, RIVERS STATE 13
- Rufus Giwa Polytechnic, Owo, Ondo State 2
- Saadatu Rimi College of Edu, Kumbotso, Kano State (affiliated To Abu, Zaria) 1
- Salem University, Lokoja, Kogi State 4
- School of Health Information Mgt (Uch, Ibadan), Oyo State 5
- School of Health Information Mgt, Oau Teaching Hospital, Ile-Ife, Osun State 30
- Skyline University Nigeria, Kano, Kano State 2