Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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Institutions
- Federal College of Education (Tech), Gusau, (Affl To Abu Zaria), Zamfara State 1
- Federal College of Education, Abeokuta (Aff To University of Ibadan), Ogun State 2
- Federal College of Education, Eha-Amufu, Enugu State 1
- Federal College of Education, Kano (Affl To Ahmadu Bello University, Zaria) 1
- Federal College of Education, Kontagora, (Affl To Abu, Zaria), Niger State 2
- Federal College of Education, Okene, (Affl. To University of Ibadan), Kogi State 3
- Federal College of Education, Pankshin, (Affl To Uni of Jos), Plateau State 2
- Federal College of Education, Zaria, Kaduna State (affl To Abu, Zaria) 1
- Federal College of Wildlife Management, New Bussa, Niger State 1
- Federal Cooperative College, Ibadan P.m.b. 5033, Eleyele, Ibadan, Oyo State 3