Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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Institutions
- Adeseun Ogundoyin Polytechnic, Eruwa, Oyo State 1
- Adeyemi College of Education, Ondo State. (affl To Oau, Ile-Ife) 68
- Ahmadu Bello University, Zaria, Kaduna State 101
- Air Force Institute of Technology (Degree), Kaduna, Kaduna State 11
- Air Force Institute of Technology, Kaduna, Kaduna State 2
- Akanu Ibiam Federal Polytechnic, Unwana, Afikpo, Ebonyi State 6
- Akwa Ibom State University, Ikot-Akpaden, Akwa Ibom State 53
- Akwa Ibom State College of Edu, Afaha-Nsit (Affl To Uni Uyo), Akwa Ibom State 2
- AKWA-IBOM STATE POLYTECHNIC (IEI), IKOT-OSURUA, AKWA IBOM STATE 41
- Akwa-Ibom State Polytechnic, Ikot-Osurua, Akwa Ibom State 32