Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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Institutions
- Binyaminu Usman Polytechnic, Hadijia, Jigawa State 3
- Borno State University, Maiduguri, Borno State 15
- Bowen University, Iwo, Osun State 1
- Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 254
- College of Agriculture and Animal Science, Mando Road, Kaduna, Kaduna State 1
- College of Agriculture, Science and Technology, Lafia, Nasarawa State 8
- College of Education, Akwanga (affl To Ahmadu Bello Univ, Zaria) 1
- College of Education, Eha Amufu, (Affliliated To Unn), Enugu State 1
- College of Education, Warri (Affiliated To Delta State Uni, Abraka), Delta State 1
- College of Health Technology, Calabar, Cross River State 1