Evaluation of the Physicochemical, in Vivo Analgesic and Anti-Inflammatory Properties of Palisota Hirsuta Ethanolic Extract Loaded Niosomal Gels
Student: Peace Ngozi Ossai (Project, 2025)
Department of Pharmacy
Delta State University, Abraka, Delta State
Abstract
This study evaluated the physicochemical, in vivo analgesic and anti-inflammatory properties of Palisota hirsuta ethanolic extract loaded niosomal gels. Ethanolic leaf extract of Palisota hirsuta was prepared and subjected to phytochemical screening, revealing the presence of bioactive compounds. The extract was incorporated into niosomal gels which were then evaluated for physicochemical properties such as pH, spreadability, viscosity, and stability. In vivo studies using animal models demonstrated that both the extract and the niosomal formulations possessed significant analgesic and anti-inflammatory activities compared to controls. The results highlight the therapeutic potential of Palisota hirsuta when formulated in novel drug delivery systems such as niosomal gels.
Keywords
For the full publication, please contact the author directly at: ossai.ngozi@delsu.edu.ng
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- AVE-MARIA UNIVERSITY, PIYANKO, NASARAWA STATE 1
- Babcock University, Ilishan-Remo, Ogun State 7
- Bamidele Olumilua University of Edu. Science and Tech. Ikere Ekiti, Ekiti State 455
- Bauchi State College of Agriculture, Bauchi, Bauchi State 1
- Bauchi State University, Gadau, Bauchi State 16
- Bayelsa State Polytechnic, Aleibiri, Bayelsa State 13
- Bayero University, Kano, Kano State 586
- Benue State Polytechnic, Ugbokolo, Benue State 10
- Benue State University, Makurdi, Benue State 47
- Bingham University, Karu, Nasarawa State 3