Synergistic Effects of Intermittent Fasting and Vitamin C on Liver Histology, Body Weight, and Fasting Blood Glucose in Glucose-Loaded Male Wistar Rats

Student: Ahmed Opeyemi Saheed (Project, 2025)
Department of Human Physiology
University of Ilorin, Kwara State

Abstract

The study evaluated the combined effects of intermittent fasting (IF) and Vitamin C on liver histology, body weight, and fasting blood glucose (FBG) in glucose-loaded male Wistar rats. While initial FBG levels were similar across groups, significant differences emerged by Week 3 and Week 5. Histological analysis revealed severe liver damage in the glucose-only group, moderate improvement with IF alone, and near-normal liver structure in the IF + Vitamin C group. These findings suggest a strong synergistic effect in reversing glucose-induced liver injury and restoring metabolic balance.

Keywords
Liver histology body weight blood glucose metabolism
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